{"id":1546,"date":"2023-10-17T03:01:43","date_gmt":"2023-10-17T03:01:43","guid":{"rendered":"https:\/\/ckd-ce.com\/?p=1546"},"modified":"2023-10-17T12:09:30","modified_gmt":"2023-10-17T12:09:30","slug":"foundation10","status":"publish","type":"post","link":"https:\/\/ckd-ce.com\/foundation10\/","title":{"rendered":"Nirogacestat and Hypophosphatemia"},"content":{"rendered":"\n<blockquote class=\"twitter-tweet\"><p lang=\"en\" dir=\"ltr\">1b) This is part of a foundational \ud83e\uded8 <a href=\"https:\/\/twitter.com\/hashtag\/MedEd?src=hash&amp;ref_src=twsrc%5Etfw\">#MedEd<\/a> <a href=\"https:\/\/twitter.com\/hashtag\/accredited?src=hash&amp;ref_src=twsrc%5Etfw\">#accredited<\/a> series hosted by core <a href=\"https:\/\/twitter.com\/ckd_ce?ref_src=twsrc%5Etfw\">@ckd_ce<\/a> faculty <a href=\"https:\/\/twitter.com\/sophia_kidney?ref_src=twsrc%5Etfw\">@sophia_kidney<\/a>. See prior <a href=\"https:\/\/twitter.com\/hashtag\/tweetorials?src=hash&amp;ref_src=twsrc%5Etfw\">#tweetorials<\/a>, still available for \ud83c\udd93CE\/<a href=\"https:\/\/twitter.com\/hashtag\/CME?src=hash&amp;ref_src=twsrc%5Etfw\">#CME<\/a> credit, at <a href=\"https:\/\/t.co\/wBHAVb7FEi\">https:\/\/t.co\/wBHAVb7FEi<\/a>.<\/p>&mdash; @CKD_ce (@ckd_ce) <a href=\"https:\/\/twitter.com\/ckd_ce\/status\/1714249230552875435?ref_src=twsrc%5Etfw\">October 17, 2023<\/a><\/blockquote> <script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script>\n\n\n\n<blockquote class=\"twitter-tweet\"><p lang=\"en\" dir=\"ltr\">3) So . . . let&#39;s start by getting you to do some lateral thinking!<br>Can you connect these 2\u20e3 graphics? <a href=\"https:\/\/t.co\/HeswUloqNc\">pic.twitter.com\/HeswUloqNc<\/a><\/p>&mdash; @CKD_ce (@ckd_ce) <a href=\"https:\/\/twitter.com\/ckd_ce\/status\/1714249234273198430?ref_src=twsrc%5Etfw\">October 17, 2023<\/a><\/blockquote> <script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script>\n\n\n\n<blockquote class=\"twitter-tweet\"><p lang=\"en\" dir=\"ltr\">5a)\ud83d\udc8a<a href=\"https:\/\/twitter.com\/hashtag\/Nirogacestat?src=hash&amp;ref_src=twsrc%5Etfw\">#Nirogacestat<\/a>: a small-molecule inhibitor of the \u03b3-secretase enzyme complex, responsible for the proteolytic cleavage of <a href=\"https:\/\/twitter.com\/hashtag\/NOTCH?src=hash&amp;ref_src=twsrc%5Etfw\">#NOTCH<\/a> (Neurogenic locus notch homolog protein receptor), is one treatment option for <a href=\"https:\/\/twitter.com\/hashtag\/desmoid?src=hash&amp;ref_src=twsrc%5Etfw\">#desmoid<\/a> tumors<\/p>&mdash; @CKD_ce (@ckd_ce) <a href=\"https:\/\/twitter.com\/ckd_ce\/status\/1714249245685891313?ref_src=twsrc%5Etfw\">October 17, 2023<\/a><\/blockquote> <script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script>\n\n\n\n<blockquote class=\"twitter-tweet\"><p lang=\"en\" dir=\"ltr\">6) Here we discuss <a href=\"https:\/\/twitter.com\/hashtag\/nirogacestat?src=hash&amp;ref_src=twsrc%5Etfw\">#nirogacestat<\/a> &amp; hypophosphatemia, re an observation in <a href=\"https:\/\/twitter.com\/KIReports?ref_src=twsrc%5Etfw\">@KIReports<\/a> from <a href=\"https:\/\/twitter.com\/gudnephron?ref_src=twsrc%5Etfw\">@gudnephron<\/a> <a href=\"https:\/\/twitter.com\/renalmyeloma?ref_src=twsrc%5Etfw\">@renalmyeloma<\/a> <a href=\"https:\/\/twitter.com\/kdjhaveri?ref_src=twsrc%5Etfw\">@kdjhaveri<\/a> in reference to <a href=\"https:\/\/t.co\/WiL2uriJub\">https:\/\/t.co\/WiL2uriJub<\/a> in <a href=\"https:\/\/twitter.com\/NEJM?ref_src=twsrc%5Etfw\">@NEJM<\/a>.<br>And here is the link to the <a href=\"https:\/\/twitter.com\/KIReports?ref_src=twsrc%5Etfw\">@KIReports<\/a> commentary:<a href=\"https:\/\/t.co\/55SHYUjxn7\">https:\/\/t.co\/55SHYUjxn7<\/a><\/p>&mdash; @CKD_ce (@ckd_ce) <a href=\"https:\/\/twitter.com\/ckd_ce\/status\/1714249249339134358?ref_src=twsrc%5Etfw\">October 17, 2023<\/a><\/blockquote> <script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script>\n\n\n\n<blockquote class=\"twitter-tweet\"><p lang=\"en\" dir=\"ltr\">8) Results:<br>\ud83d\udcccPts receiving nirogacestat had a 71% \u2b07\ufe0f risk of disease progression or death vs those on placebo<br>\ud83d\uddd3\ufe0fAfter 2 years, chances of disease-free progression were 76% on <a href=\"https:\/\/twitter.com\/hashtag\/nirogacestat?src=hash&amp;ref_src=twsrc%5Etfw\">#nirogacestat<\/a> vs 44% on placebo <a href=\"https:\/\/t.co\/ndeffIYf5A\">pic.twitter.com\/ndeffIYf5A<\/a><\/p>&mdash; @CKD_ce (@ckd_ce) <a href=\"https:\/\/twitter.com\/ckd_ce\/status\/1714249254338736241?ref_src=twsrc%5Etfw\">October 17, 2023<\/a><\/blockquote> <script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script>\n\n\n\n<blockquote class=\"twitter-tweet\"><p lang=\"en\" dir=\"ltr\">10) So, \ud83e\udd14. . . \ud83d\udcccWas <a href=\"https:\/\/twitter.com\/hashtag\/hypophosphatemia?src=hash&amp;ref_src=twsrc%5Etfw\">#hypophosphatemia<\/a> observed in other cancers tx&#39;d with \u03b3-secretase inhibitors? \ud83d\udcccWell, here is a summary of studies published in the <a href=\"https:\/\/twitter.com\/KIReports?ref_src=twsrc%5Etfw\">@kireports<\/a> piece \ud83d\udcccCould this mean it is a \u2018\u2019class effect\u2019\u2019? What would be the proposed mech?<a href=\"https:\/\/t.co\/55SHYUjxn7\">https:\/\/t.co\/55SHYUjxn7<\/a> <a href=\"https:\/\/t.co\/zIUFco0DrW\">pic.twitter.com\/zIUFco0DrW<\/a><\/p>&mdash; @CKD_ce (@ckd_ce) <a href=\"https:\/\/twitter.com\/ckd_ce\/status\/1714249258436534636?ref_src=twsrc%5Etfw\">October 17, 2023<\/a><\/blockquote> <script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script>\n\n\n\n<blockquote class=\"twitter-tweet\"><p lang=\"en\" dir=\"ltr\">11b) Perhaps it should . . . sodium phosphate transporter-2b is primarily responsible for reabsorption of phosphates in the kidneys . . . so if <a href=\"https:\/\/twitter.com\/hashtag\/nirogacestat?src=hash&amp;ref_src=twsrc%5Etfw\">#nirogacestat<\/a> has an effect there &amp; induces renal phosphorus wasting . . . <a href=\"https:\/\/t.co\/gwAiQxKLPy\">pic.twitter.com\/gwAiQxKLPy<\/a><\/p>&mdash; @CKD_ce (@ckd_ce) <a href=\"https:\/\/twitter.com\/ckd_ce\/status\/1714249262324699455?ref_src=twsrc%5Etfw\">October 17, 2023<\/a><\/blockquote> <script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script>\n\n\n\n<blockquote class=\"twitter-tweet\"><p lang=\"en\" dir=\"ltr\">12b) Should also check out levels of phosphaturic hormones such as parathyroid hormone <a href=\"https:\/\/twitter.com\/hashtag\/PTH?src=hash&amp;ref_src=twsrc%5Etfw\">#PTH<\/a> and fibroblast growth factor-23 in pts treated with <a href=\"https:\/\/twitter.com\/hashtag\/nirogacestat?src=hash&amp;ref_src=twsrc%5Etfw\">#nirogacestat<\/a>. NTK as nirogacestat is becoming <a href=\"https:\/\/twitter.com\/hashtag\/SOC?src=hash&amp;ref_src=twsrc%5Etfw\">#SOC<\/a> for <a href=\"https:\/\/twitter.com\/hashtag\/desmoid?src=hash&amp;ref_src=twsrc%5Etfw\">#desmoid<\/a> tumors! <a href=\"https:\/\/t.co\/fvUtJNVq8w\">pic.twitter.com\/fvUtJNVq8w<\/a><\/p>&mdash; @CKD_ce (@ckd_ce) <a href=\"https:\/\/twitter.com\/ckd_ce\/status\/1714249265864696210?ref_src=twsrc%5Etfw\">October 17, 2023<\/a><\/blockquote> <script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script>\n\n\n\n<blockquote class=\"twitter-tweet\"><p lang=\"en\" dir=\"ltr\">14a) And a couple \u2753s to answer! First, blocking <a href=\"https:\/\/twitter.com\/hashtag\/NOTCH?src=hash&amp;ref_src=twsrc%5Etfw\">#NOTCH<\/a> signaling in a pt with a susceptible tumor causes what?<br>a. tumor cell apoptosis<br>b. slower tumor cell growth<br>c. immune response to tumor<br>d. all of the above<\/p>&mdash; @CKD_ce (@ckd_ce) <a href=\"https:\/\/twitter.com\/ckd_ce\/status\/1714249282142732589?ref_src=twsrc%5Etfw\">October 17, 2023<\/a><\/blockquote> <script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script>\n\n\n\n<blockquote class=\"twitter-tweet\"><p lang=\"en\" dir=\"ltr\">14c) Turns out <a href=\"https:\/\/twitter.com\/hashtag\/phosphates?src=hash&amp;ref_src=twsrc%5Etfw\">#phosphates<\/a> are rather promiscuous, with levels being directly affected by NaPi-IIb, <a href=\"https:\/\/twitter.com\/hashtag\/calcitonin?src=hash&amp;ref_src=twsrc%5Etfw\">#calcitonin<\/a>, FGF-23, <a href=\"https:\/\/twitter.com\/hashtag\/parathyroid?src=hash&amp;ref_src=twsrc%5Etfw\">#parathyroid<\/a> hormone, <a href=\"https:\/\/twitter.com\/hashtag\/thyroxine?src=hash&amp;ref_src=twsrc%5Etfw\">#thyroxine<\/a>, <a href=\"https:\/\/twitter.com\/hashtag\/ACTH?src=hash&amp;ref_src=twsrc%5Etfw\">#ACTH<\/a>, and others . . . but not a, <a href=\"https:\/\/twitter.com\/hashtag\/aldosterone?src=hash&amp;ref_src=twsrc%5Etfw\">#aldosterone<\/a>. Good job!<\/p>&mdash; @CKD_ce (@ckd_ce) <a href=\"https:\/\/twitter.com\/ckd_ce\/status\/1714249286169354717?ref_src=twsrc%5Etfw\">October 17, 2023<\/a><\/blockquote> <script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script>\n\n\n\n<blockquote class=\"twitter-tweet\"><p lang=\"en\" dir=\"ltr\">15) And with that, you just earned 0.5hr\ud83c\udd93CE\/<a href=\"https:\/\/twitter.com\/hashtag\/CME?src=hash&amp;ref_src=twsrc%5Etfw\">#CME<\/a>! Claim your certificate NOW at <a href=\"https:\/\/t.co\/5SxrUAagNo\">https:\/\/t.co\/5SxrUAagNo<\/a>. Thanks for following this \ud83e\uddf5! Get more <a href=\"https:\/\/twitter.com\/hashtag\/MedEd?src=hash&amp;ref_src=twsrc%5Etfw\">#MedEd<\/a> <a href=\"https:\/\/twitter.com\/hashtag\/nephtwitter?src=hash&amp;ref_src=twsrc%5Etfw\">#nephtwitter<\/a> by FOLLOWING <a href=\"https:\/\/twitter.com\/ckd_ce?ref_src=twsrc%5Etfw\">@ckd_ce<\/a>.<br>Thanks to guest faculty <a href=\"https:\/\/twitter.com\/happiedoc?ref_src=twsrc%5Etfw\">@happiedoc<\/a> !<br>\ud83d\ude4f<a href=\"https:\/\/twitter.com\/KIReports?ref_src=twsrc%5Etfw\">@Kireports<\/a> <a href=\"https:\/\/twitter.com\/ISNkidneycare?ref_src=twsrc%5Etfw\">@ISNkidneycare<\/a> <a href=\"https:\/\/twitter.com\/academiccme?ref_src=twsrc%5Etfw\">@academiccme<\/a> <a href=\"https:\/\/twitter.com\/sophia_kidney?ref_src=twsrc%5Etfw\">@sophia_kidney<\/a><\/p>&mdash; @CKD_ce (@ckd_ce) <a href=\"https:\/\/twitter.com\/ckd_ce\/status\/1714249287700287685?ref_src=twsrc%5Etfw\">October 17, 2023<\/a><\/blockquote> <script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script>\n\n\n\n<iframe\n      id=\"JotFormIFrame-232888994100162\"\n      title=\"foundation10 | CKD CE 2023new\"\n      onload=\"window.parent.scrollTo(0,0)\"\n      allowtransparency=\"true\"\n      allowfullscreen=\"true\"\n      allow=\"geolocation; microphone; camera\"\n      src=\"https:\/\/form.jotform.com\/232888994100162\"\n      frameborder=\"0\"\n      style=\"min-width:100%;max-width:100%;height:1539px;border:none;\"\n      scrolling=\"no\"\n    >\n    <\/iframe>\n    <script type=\"text\/javascript\">\n    var ifr = document.getElementById(\"JotFormIFrame-232888994100162\");\n    if (ifr) {\n      var src = ifr.src;\n      var iframeParams = [];\n      if (window.location.href && window.location.href.indexOf(\"?\") > -1) {\n        iframeParams = iframeParams.concat(window.location.href.substr(window.location.href.indexOf(\"?\") + 1).split('&'));\n      }\n      if (src && src.indexOf(\"?\") > -1) {\n        iframeParams = iframeParams.concat(src.substr(src.indexOf(\"?\") + 1).split(\"&\"));\n        src = src.substr(0, src.indexOf(\"?\"))\n      }\n      iframeParams.push(\"isIframeEmbed=1\");\n      ifr.src = src + \"?\" + iframeParams.join('&');\n    }\n    window.handleIFrameMessage = function(e) {\n      if (typeof e.data === 'object') { return; }\n      var args = e.data.split(\":\");\n      if (args.length > 2) { iframe = document.getElementById(\"JotFormIFrame-\" + args[(args.length - 1)]); } else { iframe = document.getElementById(\"JotFormIFrame\"); }\n      if (!iframe) { return; }\n      switch (args[0]) {\n        case \"scrollIntoView\":\n          iframe.scrollIntoView();\n          break;\n        case \"setHeight\":\n          iframe.style.height = args[1] + \"px\";\n          if (!isNaN(args[1]) && parseInt(iframe.style.minHeight) > parseInt(args[1])) {\n            iframe.style.minHeight = args[1] + \"px\";\n          }\n          break;\n        case \"collapseErrorPage\":\n          if (iframe.clientHeight > window.innerHeight) {\n            iframe.style.height = window.innerHeight + \"px\";\n          }\n          break;\n        case \"reloadPage\":\n          window.location.reload();\n          break;\n        case \"loadScript\":\n          if( !window.isPermitted(e.origin, ['jotform.com', 'jotform.pro']) ) { break; }\n          var src = args[1];\n          if (args.length > 3) {\n              src = args[1] + ':' + args[2];\n          }\n          var script = document.createElement('script');\n          script.src = src;\n          script.type = 'text\/javascript';\n          document.body.appendChild(script);\n          break;\n        case \"exitFullscreen\":\n          if      (window.document.exitFullscreen)        window.document.exitFullscreen();\n          else if (window.document.mozCancelFullScreen)   window.document.mozCancelFullScreen();\n          else if (window.document.mozCancelFullscreen)   window.document.mozCancelFullScreen();\n          else if (window.document.webkitExitFullscreen)  window.document.webkitExitFullscreen();\n          else if (window.document.msExitFullscreen)      window.document.msExitFullscreen();\n          break;\n      }\n      var isJotForm = (e.origin.indexOf(\"jotform\") > -1) ? 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See prior #tweetorials, still available for \ud83c\udd93CE\/#CME credit, at https:\/\/t.co\/wBHAVb7FEi. &mdash; @CKD_ce (@ckd_ce) October 17, 2023 3) So . . . let&#39;s start by getting you to do some lateral thinking!Can you connect these 2\u20e3 graphics? pic.twitter.com\/HeswUloqNc &mdash; [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"off","_et_pb_old_content":"","_et_gb_content_width":"","_mi_skip_tracking":false,"footnotes":""},"categories":[18],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/ckd-ce.com\/wp-json\/wp\/v2\/posts\/1546"}],"collection":[{"href":"https:\/\/ckd-ce.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ckd-ce.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ckd-ce.com\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/ckd-ce.com\/wp-json\/wp\/v2\/comments?post=1546"}],"version-history":[{"count":2,"href":"https:\/\/ckd-ce.com\/wp-json\/wp\/v2\/posts\/1546\/revisions"}],"predecessor-version":[{"id":1549,"href":"https:\/\/ckd-ce.com\/wp-json\/wp\/v2\/posts\/1546\/revisions\/1549"}],"wp:attachment":[{"href":"https:\/\/ckd-ce.com\/wp-json\/wp\/v2\/media?parent=1546"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ckd-ce.com\/wp-json\/wp\/v2\/categories?post=1546"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ckd-ce.com\/wp-json\/wp\/v2\/tags?post=1546"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}